H1N1 influenza hemorrhage encephalitis: presentation of a case and review of the literature
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Keywords

Encephalitis
neurologic manifestations
influenza a virus
h1n1 subtype (MeSH)

Abstract

Neurological complications associated with respiratory viruses such as influenza, are described infrequently. Particularly influenza A(H1N1) has few descriptions most of which come from children and young adults.

We present the case of the elderly with respiratory infectious picture and multiple serious systemic complications to your primary table, who during the hospital stay has a encephalopathic box with suggestive clinical and radiologic features of hemorrhagic encephalitis due to its infectious primary agent in this case influenza A H1N1.

https://doi.org/10.22379/24224022166

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References

Rambaut A, Pybus OG, Nelson MI, Viboud C, Taubenberger JK, Holmes EC. The genomic and epidemiological dynamics of human influenza A virus. Nature. 2008;453(7195):615-9. http://dx.doi.org/10.1038/nature06945

Ekstrand JJ. Neurologic complications of influenza. Semin Pediatr Neurol. 2012;19(3):96-100. https://doi.org/10.1016/j.spen.2012.02.004

Foley PB. Encephalitis lethargica and influenza. I. The role of the influenza virus in the influenza pandemic of 1918/1919. J Neural Transm (Vienna). 2009;116(2):143-50. https://doi.org/10.1007/s00702-008-0161-1

Maricich SM, Neul JL, Lotze TE, Cazacu AC, Uyeki TM, Demmler GJ, et al. Neurologic complications associated with influenza A in children during the 2003-2004 influenza season in Houston, Texas. Pediatrics. 2004;114(5):e626-33.

Morishima T, Togashi T, Yokota S, Okuno Y, Miyazaki C, Tashiro M, et al. Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis. 2002;35(5):512-7. https://doi.org/10.1086/341407

Tsai JP, Baker AJ. Influenza-associated neurological complications. Neurocrit Care. 2013;18(1):118-30. https://doi.org/10.1007/s12028-012-9796-8

Mizuguchi M, Yamanouchi H, Ichiyama T, Shiomi M. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand Suppl. 2007;115(4 Suppl):45-56.

Takanashi J. Two newly proposed infectious encephalitis/ encephalopathy syndromes. Brain Dev. 2009;31(7):521-8. https://doi.org/10.1016/j.braindev.2009.02.012

Akins PT, Belko J, Uyeki TM, Axelrod Y, Lee KK, Silverthorn J. H1N1 encephalitis with malignant edema and review of neurologic complications from influenza. Neurocrit Care 2010;13(3):396-406. https://doi.org/10.1007/s12028-010-9436-0

Fujimoto S, Kobayashi M, Uemura O, Iwasa M, Ando T, Katoh T, et al. PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet. 1998;352(9131):873-5. https://doi.org/10.1016/S0140-6736(98)12449-2

Centers for Disease Control & Prevention (CDC). Neurologic complications associated with novel influenza A (H1N1) virus infection in children - Dallas, Texas, May 2009. MMWR. 2009;58(28):773-8.

Ito Y, Ichiyama T, Kimura H, Shibata M, Ishiwada N, Kuroki H, et al. Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy. J Med Virol. 1999;58(4):420-5.

Bermejo-Martin JF, Ortiz de Lejarazu R, Pumarola T, Rello J, Almansa R, Ramirez P, et al. Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Crit Care. 2009;13(6):R201. https://doi.org/10.1186/cc8208

Lee N, Wong CK, Chan PK, Lindegardh N, White NJ, Hayden FG, et al. Acute encephalopathy associated with influenza A infection in adults. Emerg Infect Dis. 2010;16(1):139-42. https://doi.org/10.3201/eid1601.090007

Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM, et al. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med. 2010;362(18):1708-19. https://doi.org/10.1056/NEJMra1000449

Tokuhira N, Shime N, Inoue M, Kawasaki T, Sakurai Y, Kurosaka N, et al. Mechanically ventilated children with 2009 pandemic influenza A/H1N1: results from the National Pediatric Intensive Care Registry in Japan. Pediatr Crit Care Med. 2012;13(5):e294-8. https://doi.org/10.1097/PCC.0b013e31824fbb10

Fugate JE, Lam EM, Rabinstein AA, Wijdicks EF. Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. Arch Neurol. 2010;67(6):756-8. https://doi.org/10.1001/archneurol.2010.122

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