Abstract
Meningeal criptocococis is the most common fungal infection of the central nervous system, occuring in HIV seropositive patients, although there is a significant proportion of HIV seronegative patients, in whom the presentation is more aggresive. This infection has variable clinical manifestations secondary to increased intracranial pressure. Ventriculitis with hydrocephalus is one of the complications with the poorest outcome and mortality especially in HIV seronegative patients. We present a case report of meningeal criptocococis Neoformans subtype Grubbi with ventriculitis and secondary hydrocephalus in HIV seronegative patient confirmed by histopathology.
References
MCTAGGART L, RICHARDSON SE, SEAH C, HOANG L, FOTHERGILL A, ZHANG SX. Rapid Identification of Cryptococcus neoformans var. grubii, C. neoformans var. neoformans, and C. gattii by Use of Rapid Biochemical Tests, Differential Media, and DNA Sequencing. Journal of clinical microbiology, 2011: 2522–2527
LIAO CH, CHI CY, WANG YJ, TSENG SW, CHOU CH, HO CM, ET AL. Different presentations and outcomes between HIV-infected and HIV-uninfected patients with Cryptococcal meningitis. Journal of Microbiology, Immunology and Infection 2012; 45: 296e304
LIZARAZO J, LINARES M, DE BEDOUT C, RESTREPO A, AGUDELO CI, CASTAñEDA E. Grupo Colombiano para el Estudio de la Criptococosis. Estudio clínico y epidemiológico de la criptococosis en Colombia: resultados de nueve años de la encuesta nacional,1997-2005. Biomedica. 2007;27:94-109.
ESCANDÓN P, DE BEDOUT C, LIZARAZO J, AGUDELO CI, TOBÓN A, BELLO S, ET AL. Grupo Colombiano para el Estudio de la Criptococosis. Criptococosis en Colombia: resultados de la encuesta nacional, 2006-2010. Biomedica. 2012;32:386-98.
LIZARAZOA J, CASTAñEDA E. Consideraciones sobre la criptococosis en los pacientes con sida. Infectio. 2012;16(Supl 3): 94-99.
PERFECT JR, DURACK DT. Fungal meningitis. In: Infections of the Central Nervous System. 2nd ed. Scheld WM, Whitely RJ, Durack DT, Eds. Lippincott-Raven Publishers, Philadelphia, 1997: 721-724.
PYRGOS V, SEITZ AE, STEINER CA, PREVOTS DR, WILLIAMSON PR. Epidemiology of Cryptococcal Meningitis in the US: 1997–2009. PLoS ONE 2013;8(2): e56269.
LILIANG PC, LIANG CL, CHANG WN, CHEN HJ, SU TM, LU K, ET AL. Shunt Surgery for Hydrocephalus Complicating Cryptococcal Meningitis in Human Immunodeficiency Virus–Negative Patients. Cryptococcal Meningitis and Hydrocephalus. Clinical Infectious Diseases 2003; 37:673–8.
Polacheck I, Hearing VJ, Kwon-Chung KJ. Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans. J. Bacteriol. 1982; 150 (3): 1212-1220.
CHANG YC, STINS MF, MCCAFFERY M, MILLER GF, PARE DR, DAM T, PAUL-SATYASEE M, KIM KS, KWONCHUNG KJ. Cryptococcal Yeast Cells Invade the Central Nervous System via Transcellular Penetration of the Blood- Brain Barrier. Infect. Immun. 2004; 72 (9): 4985-4995.
JARVIS JN, CASAZZA JP, STONE HH, MEINTJES G, LAWN SD, LEVITZ SM, HARRISON TS, KOUP RA. The Phenotype of the Cryptococcus-Specific CD4+ Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIVAssociated Cryptococcal Meningitis. The Journal of Infectious Diseases 2013;207:1817–28.
P. SATISHCHANDRA, T. MTAHEW, G GADRE, S. NAGARATHNA, A. CHANDRAMUKHI, A. MAHADEVAN Y S.K SHANKAR. Cryptococcal meningitis: clinical, diagnostic and therapeutic overviews. Neurol India. Jul-Sep;55(3):226-32.
JACKSON A, VAN DER HORST C. New Insights in the Prevention, Diagnosis, and Treatment of Cryptococcal Meningitis. Curr HIV/AIDS Rep 2012; 9:267–277.
RS. DOMINIC, H. PRASHANTH, S. SHENOY, S. BALIGA. Diagnostic Value of Latex Agglutination in Cryptococcal Meningitis. J Lab Physicians. 2009 Jul;1(2):67-8.
Patil SA, Katyayani S, Arvind N. Significance of antibody detection in the diagnosis of cryptococcal meningitis. Journal of immunoassay and immunochemistry 2012; 33:140–148.
Graybill JR, Sobel J, Saag M, van Der Horst C, Powderly W, Cloud G, et al. Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups. Clin Infect Dis 2000;30:47-54.

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