Abstract
INTRODUCTION: multiple sclerosis is the most common disabling neurological disease in youth adults. So far there is no accurate test for diagnosis. The laboratory tests have become very important because include assessment of intrathecal antibody production in the diagnosis of this disease.
OBJETIVE: describe the behavior of cerebrospinal fluid oligoclonal bands in a group of patients
MATERIAL AND METHODS: a descriptive case series, with the population of MS patients currently receiving specific treatment in the Hospital Militar Central in Bogota. The absolute frequencies and measures of central tendency of the variables studied were calculated.
RESULTS: among the population described there are 26 patients with MS, with a mean age of 43 years old (SD +/- 8.542). 75.1% (19) were females and 26.9% (7) male. 50% (13) of patients had positive oligoclonal bands..
CONCLUSION: with a standardized technique for determining oligoclonal bands in cerebrospinal fluid, as the high-resolution agarose gel electrophoresis the authors obtained similar results as reported in the international literature. It should make all efforts to introduce the detection of BO with the internationally recommended technique named "isoelectric focusing", who simultaneously compared serum and cerebrospinal fluid, that can get a great sensitivity and a high negative predictive value.
References
BURTON JM, O'CONOR P. Multiple sclerosis clinical trial design and analysis. Continuum. 2004; 10: 173-96.
KALMAN B, BRANNAGAN TH. Neuroimmunol-ogy in clinical practice. Oxford: Blackwell Publishing; 2008: (Part II); 29-82.
ROPPER AH, BROWN RH. ADAMS AND VICTOR'S, Principles of Neurology. The McGraw-Hill Companies. United States of America. Part 4 (36), 771-796.
SÁNCHEZ JL, AGUIRRE C, ARCOS-BURGOS OM, JIMÉNEZ I, JIMÉNEZ M, LEÓN F, ET AL. Prevalencia de la esclerosis múltiple en Colombia. Rev Neurol. 2000; 31: 1101-3.
TORO J, SARMIENTO OL, DÍAZ DEL CASTILLO A, SATIZÁBAL CL, RAMÍREZ JD, MONTENEGRO AC, ET AL. Prevalence of Multiple Sclerosis in Bogotá, Colombia. Neuroepidemiology. 2007; 28: 33-8.
BAR-OR A. The immunology of multiple sclerosis. Semin Neurol. 2008; 28: 29-45.
ÁLVAREZ-CERMEÑO JC, ARROYO R, ARBIZU T, DE ANDRÉS C, BLASCO R, CASANOVA B, ET AL. Guía oficial para el diagnóstico y tratamiento de la esclerosis múltiple. Barcelona: Prous Science; 2007.
POSER CM, PATY DW, SCHEINBERG L, MCDONALD WI, DAVIS FA, EBERS GC,ET AL. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983; 13: 227-31.
POLMANCH, REINGOLD SC, EDAN G, FILIPPI M, HARTUNG HP, KAPPOS L, ET AL. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol. 2005; 58: 840-6.
POLMAN CH, REINGOLD SC, BAMWELL B, CLANET M, COHEN JA, FILIPPI M, ET AL. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011; 69: 292-302.
LINK H, HUANG YM. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol. 2006; 180: 17-28.
AW AD A, HEMMER B, HARTUNG HP, KIESEIER B, BENNETT JL, STUVE O. Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis. J Neuroimmunol. 2010; 219: 1-7.
FREEDMAN MS, THOMPSON EJ, DEISEN-HAMMER F, GIOVANNONI G, GRIMSLEY G, KEIR G, ET AL. Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement. Arch Neurol. 2005; 62: 865-70.
FORTINI AS, SANDERS EL, WEINSHENKER BG, KATZMANN JA. Cerebrospinal fluid oligoclonal bands in the diagnosis of multiple sclerosis. Isoelectric focusing with IgG immunoblotting compared with high-resolution agarose gel electrophoresis and cerebrospinal fluid IgG index. Am J Clin Pathol. 2003; 120: 672-5.
LUNDING J,MIDGARD R, VEDELER CA. Oligoclonal bands in cerebrospinal Fluid: a comparative study of isoelectric focusing, agarose gel electrophoresis and IgG index. Acta Neurol Scand. 2000: 102: 322-5.
KEREN DF. Optimizing detection of oligoclonal bands in cerebrospinal fluid by use of isoelectric focusing with IgG immunoblotting. Am J Clin Pathol. 2003; 120: 649-51.
MASJUAN J, ÁLVAREZ-CERMEÑO JC, GARCÍA-BARRAGÁN N, DÍAZ-SÁNCHEZ M, ESPINO M, SÁDABA MC, ET AL. Clinically isolated síndromes: A new oligoclonal band test accurately predicts conversión to MS. Neurology. 2006; 66: 576-8.
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