Resumen
La trombosis de senos venosos cerebrales (TSVC) es una patología poco común del sistema nervioso central, con una mortalidad cercana al 9%. El manejo de esta enfermedad es usualmente médico. Algunos eventos de TSVC pueden tomar un curso maligno en los casos donde la presión intracraneana aumenta excesivamente. Este aumento de la presión intracraneana puede deberse a edema del tejido cerebral por el impedimento del retorno venoso y en ocasiones se asocia a hemorragia intracerebral. Se ha visto una evolución favorable cuando se realizan diagnóstico y tratamiento tempranos. Se han descrito varias técnicas de manejo endovascular que han ayudado a mejorar el flujo venoso en esta patología; sin embargo, hasta el momento sólo son pequeñas series de casos, sin evidencia suficiente para recomendarla de rutina. La mayoría de los médicos no tienen muy claro el papel con el cual interviene el neurocirujano en el manejo de la TSVC. Hay diferentes procedimientos quirúrgicos que se deben tener en cuenta, entre los cuales se encuentra la craniectomía descompresiva, cuando existe hipertensión endocraneana severa o maligna, siendo ésta la única opción terapéutica para reducir la morbimortalidad.
Citas
Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med 2005; 352: 1791-1798.
Ekseth K, Bostrom S. Reversibility of severe sagittal sinus trombosis with open surgical thrombectomy combined with local infusión of tissue plasminogen activator. Neurosur- gery 1998; 43: 960-964.
Enam SA. Role of surgery in cerebral venous sinus thrombosis. J Pak Med Assoc 2006; 56: 543-547.
Stam J, Majoie CB, Van Delden OM, Van Lienden KP, Reekers JA. Endovascular thrombectomy and thrombolysis for severe cerebral sinus thrombosis: a prospective study. Stroke 2008; 39: 1487-1490.
Canhão P, Falcão F, JM F. Thrombolytics for cerebral sinus thrombosis: a systematic review. Cerebrovasc Disease 2003; 15: 159-166.
Kalbag R, Woolf A. Cerebral Venous Thrombosis. London: Oxford University Press; 1967.
Hameed B, Syed NA. Prognostic indicators in cere- bral venous sinus thrombosis. J Pak Med Assoc 2006; 56: 551-554.
Lindgren A. Long-Term Prognosis of Cerebral Vein and Sinus Thrombosis. In: Caso V, Agnelli GP, editors. Handbook on cerebral venous thrombosis. Basel: Karger; 2008:172-178.
Ferro JM, Canhao P, Stam J, Bousser MG, Barinagar- rementeria F. SCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35: 664-670.
Ferro JM, Canhão P, Stam J. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35: 664-670.
Chater Cure G, García N, Peña G, Jiménez E. Hemor- ragia subaracnoidea: presentación inusual de una trombosis de senos venosos. Rev Chil Neurocirug 2008; 30: 68-72.
Ferro JM, Canhão P. Complications of Cerebral Vein and Sinus Thrombosis. In: Caso V, Agnelli GP, editors. Handbook on cerebral venous thrombosis. Basel: Karger; 2008:161-171.
Limber J. Cerebral venous sinus trombosis. Q J Med 2002; 95: 137-142.
Villringer A, Mehraein S, Einhäupl KM. Pathophysi- ological aspects of cerebral sinus venous thrombosis. J
Neuroradiol 1994; 21: 72-80.
Yoshikawa T, Abe O, Tsuchiya K. Diffusion-weighted magnetic resonance imaging of dural sinus thrombosis. Neuroradiology 2002; 44:481-488.
Corvol JC, Oppenheim C, Manai R, Logak M, Dormont D, Samson Y et al. Diffusion-weighted magnetic resonance imaging in a case of cerebral venous thrombosis. Stroke 1998; 29: 2649-2652.
Baumgartner RW SA, Arnold M, Georgiadis D. Recanal- isation of cerebral venous thrombosis. J Neurol Neurosurg Psychiatry 2003; 74: 459-461.
Poon CS, Chang JK, Swarnkar A, Johnson MH, Wasenko
J. Radiologic diagnosis of cerebral venous thrombosis: picto- rial review. AJR Am J Roentgenol 2007; 189(6 Supl): 64-75.
Kim B, Do H, Marks MP. Diagnosis and Management of Cerebral Venous and Sinus Thrombosis. Seminars Cere- brovascular Disease. Stroke 2004; 4: 205-216.
Keller E, Flacke S, Urbach H, Schild HH. Diffusion- and perfusion-weighted magnetic resonance imaging in deep cerebral venous thrombosis. Stroke 1999; 30: 1144-1146.
Selim M, Caplan L. Radiological Diagnosis of Cere- bral Venous Thrombosis. In: Caso V, Agnelli GP, editors. Handbook on cerebral venous thrombosis. Basel: Karger; 2008:96-111.
Selim M, Fink J, Linfante I, Kumar S, Schlaug G, Caplan LR. Diagnosis of cerebral venous thrombosis with echo-planar T2*-weighted magnetic resonance imaging. Arch Neurol 2002; 59: 1021-1026.
Connor SE, Jarosz JM. Magnetic resonance imaging of cerebral venous sinus thrombosis. Clin Radiol 2002; 57: 449-461.
Imada Y, Ikawa F, Kawamoto H, Ohbayashi N, Matushige T, Kajihara Y, et al. [Usefulness of diffusion- weighted magnetic resonance imaging in diagnosis and therapeutic strategy of deep cerebral venous thrombosis: a case report]. No Shinkei Geka 2004; 32: 285-289.
Noguchi K, Hamada H, Kubo M, Shimizu M, Seto H. Acute dural venous sinus thrombosis without brain paren- chymal abnormality: assessment with cerebral blood volume using dynamic susceptibility contrast magnetic resonance imaging. Radiat Med 2006; 24: 635-638.
Hayashi T, Miyazaki H, Toda Y, Ishiyama N. Single photon emission computed tomography of reversible magnetic resonance imaging abnormalities of deep cerebral venous thrombosis accompanied with malignant glioma. Surg Neurol 2007; 67(2): 195-199; discussion 199.
Soman R, Kundalia HK. Magnetic resonance imaging is essential for cerebral venous thrombosis. J Assoc Physicians India 1995; 43: 494.
Bousser MG. Role of magnetic resonance imaging in cerebral venous thrombosis. J Mal Vasc 1995; 20: 189-193.
Medlock MD, Olivero WC, Hanigan WC, Wright RM, Winek SJ. Children with cerebral venous thrombosis diagnosed with magnetic resonance imaging and magnetic resonance angiography. Neurosurgery 1992; 31: 870-876; discussion 876.
Einhaupl KM, Villringer A, Meister W, Mehraein S, Garner C, Pellkofer M, et al. Heparin treatment in sinus venous thrombosis. Lancet 1991; 338: 597-600.
De Bruijn SF, JS. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight hepa- rin for cerebral sinus thrombosis. Stroke 1999; 30: 484-488.
Jain S, Bhatt P, Muralikrishna GK, Malhotra P, Kumari S, Varma S. Extensive arterial and venous thrombosis in a patient with ulcerative colitis -a case report. MedGenMed
; 7: 10.
Stam J, De Bruijn SF, DeVeber G. Anticoagulation for cerebral sinus thrombosis. Cochrane Database of Systematic Reviews 2002 (Issue 4).
DeVeber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley DJ, et al. Cerebral sinovenous thrombosis in children. N Engl J Med 2001; 345: 417-423.
Einhäupl K, Bousser MG, De Bruijn SF TM, Ferro JM, Martinelli M, Masuhr F, et al. EFNS guideline on the treat- ment of cerebral venous and sinus thrombosis. Eur J Neurol 2006; 13: 553-559.
Masuhr F, Einhäupl K. Treatment of Cerebral Venous and Sinus Thrombosis. In: Caso V, Agnelli GP, editors. Handbook on cerebral venous thrombosis. Basel: Karger; 2008:132-143.
Ehtisham A, Stern BJ. Cerebral venous thrombosis: a review. Neurologist 2006; 12: 32-38.
Bousser M. Cerebral venous thrombosis: report of 76 cases. J Mal Vasc 1991; 16: 249-254.
Frey JL, Muro GJ, McDougall CG, Dean BL, Jahnke HK. Cerebral venous thrombosis: combined intrathrombus rtPA and intravenous heparin. Stroke 1999; 30: 489-494.
Wasay M, Bakshi R, Kojan S, Bobustuc G, Dubey N, Unwin DH. Nonrandomized comparison of local urokinase thrombolysis versus systemic heparin anticoagulation for superior sagittal sinus thrombosis. Stroke 2001; 32: 2310- 2317.
Agner C, Deshaies EM, Bernardini GL, Popp AJ, Boulos AS. Coronary angiojet catheterization for the management of dural venous sinus thrombosis. Technical note. J Neurosurg 2005; 103: 368-371.
Ferro JM, Canhão P, Stam J. Acute Treatment of Cere- bral Venous and Dural Sinus Thrombosis. Current Treatment Options in Neurology 2008; 10: 126-137.
Schwarz S, Daffertshofer M, Schwarz T, Georgiadis D, Baumgartner RW, Hennerici M, et al. Current controversies in the diagnosis and management of cerebral venous and dural sinus thrombosis. Nervenarzt 2003; 74: 639-653.
Caso V, Billeci AMR DL. Interventional Neuroradiol- ogy in the Treatment of Cerebral Venous Thrombosis. In: Caso V, Agnelli GP, editors. Handbook on cerebral venous thrombosis. Basel: Karger; 2008:144-160.
Kirsch J, Rasmussen PA, Masaryk TJ, Perl J, 2nd, Fiorella D. Adjunctive rheolytic thrombectomy for central venous sinus thrombosis: technical case report. Neurosurgery 2007; 60: E577-78; discussion E578.
Baker MD, Opatowsky MJ, Wilson JA, Glazier SS, Morris PP. Rheolytic catheter and thrombolysis of dural venous sinus thrombosis: a case series. Neurosurgery 2001; 48: 487-93; discussion 493-494.
Ameri A, MG B. Cerebral venous thrombosis. Neurol Clin 1992; 10: 87-111.
Stefini R, Latronico N, Cornali C, Rasulo F, Bollati
A. Emergent decompressive craniectomy inpatients with fixed dilated pupils due to cerebral venous and dural sinus thrombosis: report of three cases. Neurosurgery 1999; 45: 626-629.
Keiper GL, Sherman JD, Tomsick TA, Tew JM. Dural sinus thrombosis and pseudotumor cerebri: unexpected com- plications of suboccipital craniotomyand translabyrinthine craniectomy. J Neurosurg 1999; 91: 192-197.
Coutinho JM, Majoie CB, Coert BA, Stam J. Decom- pressive hemicraniectomy in cerebral sinus thrombosis: consecutive case series and review of the literature. Stroke 2009; 40: 2233-2235.
Keller E, Pangalu A, Fandino J, Konu D, Yonekawa
Y. Decompressive craniectomy in severe cerebral venous and dural sinus thrombosis. Acta Neurochir Suppl 2005; 94: 177-183.
Barbati G, Dalla MG, Coletta R, Blasetti AG. Post- traumatic superior sagittal sinus thrombosis. Case report and analysis of the international literature. Minerva Anestesiol 2003; 69: 919-925.
Weber J, Spring A. Unilateral decompressive craniec- tomy in left transverse and sigmoid sinus thrombosis. Zentralbl Neurochir 2004; 65: 135-140.
Zeng L, Derex L, Maarrawi J, Dailler F, Cakmak S, Nighoghossian N, et al. Lifesaving decompressive craniec- tomy in ‘malignant’ cerebral venous infarction. Eur J Neurol 2007; 14: e27-e28.
Persson L, Lilja A. Extensive dural sinus thrombosis treated by surgical removal and local streptokinase infusion. Neurosurgery 1990; 26: 117-121.
Kourtopoulos H, Christie M, Rath B. Open throm- bectomy combined with thrombolysis in massive intracranial sinus thrombosis. Acta Neurochir (Wien) 1994; 128: 171-173.
Sindou M, Mercier P, Bokor J, Brunon J. Bilateral thrombosis of the transverse sinuses: microsurgical revas- cularization with venous bypass. Surg Neurol 1980; 13: 215-220.
Canhão P, Ferro JM, Lindgren AG, Bousser MG, Stam J, Barinagarrementeria F. Causes and predictors of death in cerebral venous thrombosis. Stroke 2005; 36: 1720-1725.
Ferro JM. Causes, predictors of death, and antithrom- botic treatment in cerebral venous thrombosis. Clin Adv Hematol Oncol 2006; 4: 732-733.

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
