Complex regional pain syndromes. Controversies and recent concepts
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Keywords

Complex regional pain syndromes,
pain
muscle fibers (MeHS)

Abstract

One of the most intriguing pathologies that physicians face be dealing in his daily medical practice is the CRPS (Complex Regional Pain Syndrome).
There are several and news concepts arising from the continuous research that allow us to udjust new therapies according to each patient.
The precise place between neuropathic or inflammatory is not clear due to several mechanisms involved in its his pathophysiology. The aim of this paper is to give some lights to understand the main factors regard to clinic manifestations and treatment of this syndrome.


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References

HARDEN RN, BRUEHL SP. Diagnosis of Com- plex Regional Pain Síndrome. Signs, Symptoms, and New Empirically Derived Diagnostic Criteria; Clin J Pain 2006; 22:415-419.

JANIG W, BARON R. Is CRPS I a neuropathic pain syndrome?, Pain 2006;120: 227-229.

OAKLANDER AL, RISSMILLER J G, GELMAN L B, ZHENG L, CHANG Y, GOTT R. Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome I (reflex sympathetic dystro- phy). Pain 2006;120: 235-243.

ALBRECHT PJ, HINES S, EISENBERG E, ET AL. Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome. Pain 2006;120: 244- 266.

VAN DER LAAN L, TER LAAK HJ, GABREËLS- FESTEN A, GABREEËLS F, GORIS RJA. Complex regional pain syndrome type I (RSD). Pathology of skeletal muscle and peripheral nerve. Neurology 1998;51: 20-25.

NALESCHINSKI D, BARON R. Complex Regional Pain Syndrome Type I: Neuropathic or Not?. Curr Pain Headache Rep 2010; 14:196-202.

BIRKLEIN F, SCHMELZ M, SCHIFTER S, WEBER M. The important role of neuropep- tides in complex regional pain syndrome. Neurology 2011;57:2179-2184.

DE MOSS M, STURKENBOOM M, HUYGEN F. Current Understandings on Complex Regional Pain Syndrome. Pain Practice 2009;9: 86-99.

SCHWARTZMAN RJ, ALEXANDER GM, GRO- THUSEN J, ET AL. Pathophysiology of complex regional pain syndrome. Expert Rev. Neurotherapeutics 2006;6: 669-681.

ÜÇEYLER N, EBERLE T, ROLKE R, BIRKLEIN F, SOMMER C. Differential expression patterns of cytokines in complex regional pain syndrome. Pain 2007;132: 195 – 205.

KRÄMER HH, EBERLE T, ÜÇEYLER N WAGNER I, ET AL. TNF-alpha in CRPS and “normal” trauma-Significant differences between tissue and serum. Pain (2010).doi:10.106/j. pain.2010.09.024.

BERNATECK M, KARST M, GRATZ K, ET AL. The First Scintigraphic Detection of Tumor Necro- sis Factor-Alpha in patients with Complex Regional Pain Syndrome Type 1. Anesth Analg 2010; 110: 211- 215.

HARDEN RN. Cytokine imbalance/activity as a unifying hypothesis for the pathogenesis and patho- physiology of Complex Regional Pain Syndrome?. Pain 152 2011;152: 247-248.

LEWIS JS, KERSTEN P, MCPHERSON K, ET AL. Wherever is my arm? Impaired upper limb posi- tion accuracy in Complex Regional Pain Syndrome. Pain 2010; 149: 463-469.

SCHINKEL C, GAERTNER A, ZASPEL J, ZEDLER S, FAIST E, SCHUERMANN M. Inflam- matory Mediators are altered in the acute phase of posttraumatic Complex Regional Pain Syndrome. Clin J Pain 2006;235-239.

MAIHÓFNER C, HANDWERKER HO, NEUN- DÓRFER B, BIRKLEN F. Patterns of cortical reorganization in complex regional pain syndrome. Neurology 2003; 61: 1707-1715.

SERPELL M. Role of the sympathetic nervous system in pain. Anaesthesia and Intensive Care Medicine 2005;6 52-55.

PARRILLO SJ. Complex Regional Pain Syndrome; eMedicine. Medscape.com. Emergency Medicine,

Neurology 2010.

BRUEHL S, HARDEN RN, GALER BS, SALTZ S, BACKONJA M, STANTON.HICKS M. Complex Regional Pain Syndrome: are there distinct subtypes and sequential stages of the syndrome?. Pain 2002;95: 119-124.

HARDEN RN, BRUEHL S, STANTON-HICKS M, WILSON PT. Proposed New diagnostic Criteria for Complex Regional Pain Syndrome. Pain Medicine 2007;8 326-331.

R ALBAZAZ, WONG YT, HOMER- VANNI- ASINKAM S. Complex Regional Pain Syndrome: A Review. Ann of Vasc Surg 2008; 22: 297-306.

SCHÜRMAN M, ZASPEL J, LÖHR P, ET AL. Imaging in Early Posttraumatic Complex Regional Pain Syndrome. A comparison of diagnostic meth- ods. Clin J Pain 2007;23: 449-457.

SCHOTT GD Complex Regional Pain Syndrome. Pract Neurol 2007; 7: 145-157.

CEPEDA MS, CARR DB, LAU J. Local anes- thetic sympathetic blockade for Complex Regional Pain Syndrome (review). (2005) The Cochrane Data base of Systematic Review 2005,Issue 4 Art. No.:CD004598.pub.2DOI:10.1002/14651858.

NELSON DV. and Stacey BR Interventional Ther- apies in the Management of Complex Regional Pain Syndrome. Clin J Pain 2006; 22: 438- 442.

HARTRICK CT, KOVAN JP, NAISMITH P. Outcome Prediction Following Sympathetic Block for Complex Regional Pain Syndrome. Pain Practice 2004;4: 222-228.

WASNER G, SCHATTSCHNEIDER J, BINDER A, BARON R. Complex Regional Pain Syndrome – diagnostic, mechanisms, CNS involvement and ther- apy. Spinal Cord 2003; 41: 61-75.

HSU ES. Practical Management of Complex Regional Pain Syndrome.; American Journal of Ther- apeutics 2009:16; 147-154.

PEREZ RS, ZOLLINGER PE, DIJKSTRA PU, ET AL. Evidence based guidelines for Complex Regional Pain Syndrome Tipe I; BMC Neurology 2010;10: 1-14

DALY AE, BIALOCERKOWSKI AE. Does evi- dence support physiotherapy management of adult Complex Regional Pain Syndrome Type One? A sys- tematic review. European Journal of Pain 2009; 13:339- 353.

MACKEY S, FEINBERG S. Pharmacologic Therapies for Complex Regional Pain Syndrome. Current Pain and Headache Reports 2007; 11: 38-43.

FISCHER SGL, ZUURMOND WWA, BIRKLEIN F, LOER SA, PEREZ R. Anti-inflammatory treatment of Complex Regional Pain Syndrome; Pain 2010; 149: 251-256.

PEREZ RSGM, ZUURMOND WWA, BEZEMER PD, ET AL. The treatment of Complex Regional Pain Syndrome type I with free radical scavengers: a randomized controlled study; Pain 2003; 102: 297- 307.

ZYLUK A AND PUCHALSKI P. Treatment of Early Complex Regional Pain Syndrome Type 1 by A combination of Mannitol and Dexamethasone; J Hand Surg Eur 2008; 33: 130-136.

SINIS N, BIRBAUMER N, GUSTIN S, ET AL. Memantine Treatment of Complex Regional Pain Syndrome A Preliminary report of six cases. Clin J Pain 2007; 23; 237-243.

GUSTIN SM, SCHWARZ A, BIRBAUMER N, ET AL. NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation; Pain 2010; 151: 69-76.

KRANK VAN EIJS, STANTON-HICKS M, VAN ZUNDERT J, ET AL. 16. Complex Regional Pain Syndrome. Pain Practice 2011; 11:70-87.

BERNATECK M, ROLKE R, BIRKLEIN F, TREEDE RD, FINK M, KARST M. Successful Intra- venous regional block with low-dose Tumor necrosis Factor ? Antibody Infliximab for treatment of Com- plex Regional Pain Syndrome 1; Anesth Analg 2007; 105:1148-51.

HUYGEN FJ, NIEHOF S, ZIJLSTRA F, ET AL. Successful Treatment of CRPS 1 with Anti- TNF; Anesth Analg Letters 2004;27:101-103.

TAYLOR RS, VAN BUYTEN JP, BUCHSER E. Spinal cord stimulation for Complex Regional Pain Syndrome: A Systematic review of the clinical and cost-effectiveness literature and assessment of prognostic factors. European Journal of Pain 2006;10: 91-101.

MARIUS K, DE VET HC, BARENDSE G, VAN DEN WILDENBERG FA, VAN KLEEF M. Spinal Cord Stimulation for Chronic Reflex Sympathetic Dystrophy-Five year follow up. New Engl J Med 2006; 22: 2394.

VAN EIJS F, SMITS H, GEURTS JW, ET AL. Brush-evoked allodynia predicts outcome of spinal cord stimulation in Complex Regional Pain Syndrome type 1; European Journal of Pain 2010;14:

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