Abstract
Hemostasis is a physiologic mechanism that maintains blood in a fluid state within the circulation. The coagu- lation of blood is mediated by cellular components and soluble plasma proteins. In response to vascular injury, circulating platelets adhere, aggregate, and provide cell-surface phospholipid for the assembly of blood-clotting enzyme complexes. Blood coagulation is vital in achieving hemostasis after a vascular insult has occurred. The failure of blood to coagulate may lead to consequences associated with morbidity and mortality. A more recently proposed cell-based model better describes the coagulation process in vivo and provides neurologist with a better understanding of the clinical implications.
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