Abstract
The infiltration of local anesthetic (LA) is increasingly widespread as an indication in the treatment of neuropathic pain. AL poisoning is rare but serious, life-threatening entity and its management may be very difficult. It occurs with decreased level of consciousness, seizures and cardiac conduction blocks. The lipid emulsion (EL) 20% is the only specific treatment described to date and it has improved the prognosis of these patients. We report the case of a patient with progressive neurological deterioration after injection of high doses of LA for treat a neuropathic pain refractory to other treatments. The patient was treated with lipid emulsion 20% with reversing all the neurological symptoms early and completely. The occurrence of progressive neurological symptoms in the context of a local anesthetic infiltration, should alert us to a possible poisoning and to start early treatment with lipid emulsion 20%, to avoid poor prognosis. However, prevention remains the main tool.
References
KOSH MC, MILLER AD, MICHELS JE. Intravenous lipid emulsion for treatment of local anesthetic toxicity. Ther Clin Risk Manag.. 2010;6:449-451.
NOGUÉ S, COROMINAS N, SOY D, CINO J. Emulsion lipídica intravenosa: un nuevo antídoto para uso en reanimación. Emergencias 2011;23:378-385.
CORCORAN W, BUTTERWORTH J, WELLER RS, ET AL. Local anesthetic-induced cardiac toxicity: a survey of contemporary practice strategies among academic anesthesiology departments. Anesth Analg.2006;103:1322-1326.
NOUETTE-GAULAIN K, CAPDEVILA X, ROBIN F, BELOEIL H. Intravenous lipid emulsion and local anesthetic-induced systemic toxicity: mechanisms and limits. Ann Fr Anesth Reanim. 2014;33(6):411-7
JAMATY C, BAILEY B, LAROCQUE A, ET AL. Lipid emulsions in the treatmente of acute poisoning: a systematic reviwe of human and animal studies. Clin Toxicol (Phila). 2010;48:1-27.
PICARD J, WARD SC, ZUMPE R, MEEK T, ET AL. Guidelines and adoption o "lipid rescue" thearpy for local anaesthetic toxicity. Anaesthesia 2009;64:122-5.
ESPINET AJ, EMMERTON MT. The successful use of intralipid for treatment of local nesthetic-induced central nervous system toxicity. Some considerations for administration of intralipid in an emergency. Clin J Pain. 2009;25(9):808-809.
COLLINS S, NEUBRANDER J, VORST Z, SHEFFIELD B. Lipid Emulsion in treatment of local anesthetic toxicity. J Perianesth Nurs. 2015;30(4):308-20.
LESKIW U, WEINBERG GL. Lipid resuscitation or local anesthetic toxicity: is it really lifesaving? Curr Opin Anaesthesiol. 2009;22:667-71.
KALIL AL. Local anesthetic toxicity: reviwe and case studies. AANA J.1983;51:275-278.
Association of anaesthetists of Great Britain and Ireland. Guidelines for the management o severe local aneaesthetic toxicity. [Internte]. Lugar de publicación: editor; fecha de comienzo [fecha de última actualización; fecha de consulta]. Página web; páginas (o pantallas aproximadas). Disponible en: http://www.aagbi.org/publications/guidelines/docs/latoxictiy07.pdf.
WEINBERG G. Lipid infusión resuscitation for local anesthetic toxicity: proof of clinical efficacy. Anesthesiology 2006;105:7-8.
WEINBERG GL, RIPPER R, MURPHY P, ET AL. Lipid infusión accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med. 2006;31:296-303.
CAO D, HEARD K, FORAN M, KOYFMAN A. Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. J Emerg Med. 2015;48(3):387-97.
BANIA CT. Intravenous fat emulsions. En: Nelson LS, Lewin NA, HOwland MA, et al. Golfrank's. Toxicologic emergencies. Nueva York: Mc Graw Hill;2010;pp:976-983.
YOUNG AC, VELEZ LI, KLEINSCHEMIDT KC. Intravenous fat emulsion therapy or intentional sustained-release verapamil overdose. Resuscitacion. 2009;80:591-3.
HARCHELROAD F, PALMA A. Efficacy and safety of intraveosus lipid therapy in a beta-blocker overdose. Clin Toxicol. 2008;46:620.
WEINBERG G DI GREGORIO G, HILLER D, HEWETT A, SIRIANNI A. Reversal of haloperidol-induced cardiac arrest by using lipid emulsion. Ann Intern Med. 2009;150:737-8.
BRENT J. Poisoned patients are different-sometimes fat is a good thing. Crit Care Med.2009;37:1157-8.

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