Abstract
This chapter lists the medications used in the treatment of Parkinson's disease, reviewing their main characteristics, indications, advantages and disadvantages. Recommendations related to non-approved therapies are also given, due to absence of evidence or non-effectiveness. Finally, some of the medications that should be avoided are listed because of their risk of producing or worsening parkinsonian symptoms.
References
Poewe W Antonini A, Zijlmans JC, Burkhard PR, Vingerhoets F. Levodopa in the treatment of Parkinson's disease: an old drug still going strong. Clin Interv Aging. 2010;5:229-38.
Warren Olanow C, Kieburtz K, Rascol O, Poewe W Schapira AH, Emre M, et al. Factors predictive of the development of Levodopa-induced dyskinesia and wearing-off in Parkinson's disease. Mov Disord. 2013;28(8):1064-71.
Cilia R, Akpalu A, Sarfo FS, Cham M, Amboni M, Cereda E, et al. The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa. Brain. 2014;137(Pt 10):2731-42.
Fox SH, Katzenschlager R, Lim S-Y, Barton B, de Bie RMA, Seppi K, et al. International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson's disease. Mov Disord. 2018;33(8):1248-66.
Barone P, Poewe W Albrecht S, Debieuvre C, Massey D, Rascol O, et al. Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: A randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2010;9(6):573-80.
Rosa-Grilo M, Qamar MA, Taddei RN, Pagonabarraga J, Kulisevsky J, Sauerbier A, et al. Rotigotine transdermal patch and sleep in Parkinson's disease: where are we now? NPJ Park Dis. 2017;3:28.
Moreno López CL, Bernal Pacheco O, Barrios Vincos G, Arango Uribe G, Cerquera Cleves C, Orozco Vélez JL, et al. Consenso de la Asociación Colombiana de Neurología sobre el uso de apomorfina en la enfermedad de Parkinson. Acta Neurol Colomb. 2018;34:25-39.
A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch Neurol. 2002;59(12):1937-43.
Stocchi F, Rabey JM. Effect of rasagiline as adjunct therapy to levodopa on severity of OFF in Parkinson's disease. Eur J Neurol. 2011;18(12):1373-8.
de Souza RM, Schapira A. Safinamide for the treatment of Parkinson's disease. Expert Opin Pharmacother. 2017;18(9):937-43.
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