Abstract
INTRODUCTION. On the last decade new risk factors have gain epidemiologic importance, especially infections and chronic inflammation. Our group hypothesis is that inadequate diets and a low demographic environment can cause chronic inflammation.
OBJECTIVE. To determine the association between carotid intima media thickness and the levels of inflammatory markers.
METHODS. An analytical cross-sectional study was design in which 34 patients with ischemic stroke and 34 healthy subjects paired by age, sex and geographic origin were recruited. The study population is a small sample of the National Multicentric Study of Ischemic Stroke Risk Factors (FREC-VI). Blood samples were taken to determine general biochemistry, FNT , IL6, CRP, fibrinogen and a ECO doppler was made to measure intima media carotid thickness.
Results. CRP and IL6 plasmatic levels were significantly higher in cases compared with control subjects. Fibrinogen and FNT? didn’t showed significant differences between the groups. Intima media thickness didn’t showed differences on common and internal carotid. The OR for CRP was of 8.39 (CI95% 1.38-50.65), of 1.45 (CI95% 1.07-1.95) for IL6, of 1.11 (CI95% 0.99-1.23) for FNT?. CRP and IL6 showed a significant correlation with intima media thickness with right external carotid.
CONCLUSIONS. IL6 and CRP are inflammatory markers associated with ischemic stroke. High levels of CRP and IL6 correlate directly a major intima media thickness of right external carotid. It wasn’t found a significant association between ischemic strokes and high levels of FNT? and fibrinogen (Acta Neurol Colomb 2006;22:3-11).
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