Resumen
El síndrome de cefalea asociado a déficit neurológico y linfocitosis en el líquido cefalorraquídeo, HaNDL, por sus siglas en inglés, es una entidad de reciente descripción. Sin embargo ya está incluida en la última clasificación internacional de cefaleas y parece tener una distribución mundial. Presentamos a continuación el primer caso descrito en la literatura latinoamericana para que sus características sean tenidas en cuenta en el abordaje diagnóstico de las cefaleas.
Citas
Bartleson J, Swanson JW, Whisnant JP. A migrainous syndrome with cerebrospinal fluid pleocytosis. Neurology. 1981; 31:125-762.
Berg MJ, Williams LS. The transient syndrome of headache with neurologic déficits and CSF lymphocytosis. Neurology. 1995; 45: 1648-54.
Valença M, A. de Oliveira D, Hugo André de L. Martins, H. Alice in Wonderland Syndrome, Burning Mouth Syndrome, Cold Stimulus Headache, and HaNDL: Narrative Review Headache. 2015;55:1233-48.
Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629-808.
Morrison DG, Phuah HK, Reddy AT, Dure LS, Kline LB. Ophthalmologic involvement in the syndrome of headache, neurologic deficits, and cerebrospinal fluid lymphocytosis. Ophthalmology. 2003;110:115-118.
García Barragán N, Guillán M, Zarza B, González C, De Felipe Mimbrera A, De Leciñama MA, Masjuan J. Focal CT hypoperfusion in HaNDL. J Neurol. 2012; 259:1755-7.
Segura T, Hernandez-Fernandez F, Sanchez-Ayaso P, Lozano E, Abad L. Usefulness of multimodal MR imaging in the differential diagnosis of HaNDL and acute ischemic stroke. BMC Neurology. 2010, 10:120.
Vallet AE, Desestret V, Tahon F, Cho TH, Nighoghossian N. Acute Perfusion MR Imaging in a HaNDL-Like Syndrome. Cerebrovasc Dis 2010;29:98-100.
Barón J, Mulero P, Pedraza MI, Gamazo C, de la Cruz C, Ruiz M, Ayuso M, Cebrián MC, García-Talavera P, Marco J, Guerrero AL. HaNDL syndrome: Correlation between focal deficits topography and EEG or SPECT abnormalities in a series of 5 new cases. Neurologia. 2016 Jun;31(5):305-10.
Emond H, Schnorf H, Poloni C, Vulliemoz S, Lalive PH. Syndrome of transient headache and neurological deficits with CSF lymphocytosis (HaNDL) associated with recent human herpesvirus-6 infection. Cephalalgia. 2009;29(4):487-91.
Cifelli A, Vaithianathar L. Syndrome of transient Headache and Neurological Deficitswith cerebrospinal fluid Lymphocytosis (HaNDL). BMJ Case Reports. 2011; 10: 1-5.
Balbuena MS, Arpa-Gutierrez FJ. Pseudomigraine with cerebrospinal fluid pleocytosis or syndrome of headache, temporary neurological deficit and cerebrospinal fluid. A historical review. Rev Neurol. 2007;45(10):624-30.
Krause T, Nolte CH. The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocy-tosis (HaNDL) as an acute ischemic stroke mimic leading to systemic thrombolysis: a case report. Clin Neurol Neurosurg. 2012;114(6):689-90.
Martínez-Velasco E, Mulero P, Barón J, Amer M, Guerrero AL. Confusional state in HaNDL syndrome: an uncommon clinical manifestation. Neurol Sci (2016) 37:483-485.
Frediani F, Bussone G. Confusional state as first symptom of HaNDL síndrome. Neurol Sci. 2015;36 Suppl 1:71-4.
Babi MA, Applebee A, Shapiro R, Waheed W. Syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis presenting as acute neurological emergencies. Cephalalgia. 2017;37(3):284-89.
Martín-Cascón M. Villaverde-González R. Espinosa-Parra FJ. Meseguer-Noguera R. Syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL). Rev Clin Esp. 2015;215(4):246-7.
Athar MK, Levine JM. Treatment options for cerebral vaso-spasm in aneurysmal subarachnoid hemorrhage. Neurotherapeutics. 2012;9:37-43.

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
